Oromucosal delivery, especially that utilising the buccal and sublingual mucosa as the absorption site, is a promising drug delivery route which promotes rapid absorption and high bioavailability, with subseqent almost immediate onset of pharmacological effect. These advantages are the result of the highly vascularised oral mucosa through which drugs enter the systemic circulation directly, thus bypassing the gastrointestinal tract and the first pass effect in the liver. MFD tablet of piroxicam (PX) are subjected to in vivo pharmacokinetic evaluation to evaluate whether these systems improve oral bioavailability of the piroxicam. All the pharmacokinetic parameters of absorption, namely Ka, Cmax, Tmax, percent absorbed to various times and AUC indicated rapid absorption and higher bioavailability of piroxicam when administered as MFD Tablet. The absorption rate constant (Ka) was found to be increased compare with marketed formulation. Both Ka and AUC were markedly increased by MFD tablet. Thus, the results of pharmacokinetic studies indicated rapid and higher oral absorption of piroxicam when administered as MFD tablet.
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